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What Are Polymer Nanoparticles?

  • Polymeric nanoparticles are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure.

    1. What are characteristics of polymer nanoparticles?

    Polymer nanoparticles have favorable characteristics in terms of simple elaboration and design, good biocompatibility, broad-structure variety, and notable bioimitative characteristics. This is expressly shown in smart drug delivery where polymer nanoparticles have a marked role since they are able to bring therapeutics right into the intended position in the human body with excellent efficiency.

    1. What are advantages of polymer nanoparticles?

    Most important advantages offered by the polymer nanoparticles include the following: (1) provide controlled release to the desired site, (2) provide stability to labile molecules (e.g., proteins), and (3) provide ability to modify surfaces with ligands for stealth and targeted drug delivery purposes.

    1. How do you make polymer nanoparticles?

    There are various methods used for the preparation of polymeric nanoparticles such as desolvation, dialysis, ionic gelation, nanoprecipitation, solvent evaporation, salting out, spray drying and supercritical fluid.

    1. Polymer nanoparticles for biomedical applications?

    Polymer nanoparticles that are important from the point of view of biomedical applications can be prepared from a large number of polymers. Although there are no definite rules to qualify a polymer to be appropriate for application in the medical area, the most important conditions include nontoxicity, biocompatibility, and biodegradability. Moreover, if the polymer is intended to form a particle, it cannot be soluble under physiological conditions at least until it fulfills its role in the body.

    1. Why are polymer nanoparticles used in drug delivery?

    As polymer nanoparticles have shown remarkable superiority over intravenous and oral administration routes. In terms of drug delivery, they can be easily integrated with other activities such as tissue engineering. In addition, they transport active ingredients to a targeted tissue or organ at the specified concentration and impart stability and longer duration activity to volatile active ingredients. Moreover, these particles can be considered ideal candidates for vaccine delivery, cancer therapy, and targeted antibiotics delivery in accordance with polymer choice and capacity to adjust drug release from polymer nanoparticles.

    About the author

    CD Bioparticles provides a large selection of monodisperse polymer nanoparticles and microspheres with multiple sizes from 20 nm to 100 µm. Our DiagPoly™ spherical polymer particles are available with plain, functional or biomolecules conjugated surfaces. These polymer particles are suitable for a broad of applications in drug targeting and delivery, imaging, immunoassay, and medical devices.

    References

    1. Krug, P., Bartel, M., Głowala, P., Wysocka, B., Mojzych, I., Kwiatkowska, M., ... & Mazur, M. (2019). Organic polymer particles for biomedical applications. In Materials for Biomedical Engineering(pp. 59-111). Elsevier.
    2. Madkour, L. H. (2019). Nucleic Acids as Gene Anticancer Drug Delivery Therapy. Academic Press.
    3. Zielińska, A., Carreiró, F., Oliveira, A. M., Neves, A., Pires, B., Venkatesh, D. N., ... & Souto, E. B. (2020). Polymeric nanoparticles: Production, characterization, toxicology and ecotoxicology. Molecules, 25(16), 3731.
    4. Krishnamoorthy, K., & Mahalingam, M. (2015). Selection of a suitable method for the preparation of polymeric nanoparticles: multi-criteria decision making approach. Advanced pharmaceutical bulletin, 5(1), 57.